Relationships of circulating CD4+ T cell subsets and cytokines with the risk of relapse in patients with Crohn’s disease - CIRI - Physiopathologie et biothérapies des infections muqueuses
Article Dans Une Revue Frontiers in Immunology Année : 2022

Relationships of circulating CD4+ T cell subsets and cytokines with the risk of relapse in patients with Crohn’s disease

Anthony Buisson
  • Fonction : Auteur
Jacques Bienvenu
  • Fonction : Auteur
Cendrine Josson
  • Fonction : Auteur
Renaud Jasnowski
  • Fonction : Auteur
Stéphane Legastelois
  • Fonction : Auteur
Arnaud Foussat
  • Fonction : Auteur

Résumé

Background and aims: We aimed to analyze circulating CD4 + T cell subsets and cytokines during the course of Crohn's disease (CD).

Methods and results: CD4 + T cell subsets, ultrasensitive C-reactive protein (usCRP), and various serum cytokines (IL-6, IL-8, IL-10, IL-13, IL-17A, IL-23, TNFa, IFNg, and TGFb) were prospectively monitored every 3 months for 1 year, using multicolor flow cytometry and an ultrasensitive Erenna method in CD patients in remission at inclusion. Relapse occurred in 35 out of the 113 consecutive patients (31%). For patients in remission within 4 months prior to relapse and at the time of relapse, there was no significant difference in Th1, Th17, Treg, and double-positive CD4 + T cell subsets co-expressing either IFNg and FOXP3, IL-17A and FOXP3, or IFNg and IL-17A. On the contrary, in patients who remained in remission, the mean frequency and number of doublepositive IL-17A + FOXP3 + CD4 + T cells and the level of usCRP were significantly higher (p ≤ 0.01) 1 to 4 months prior to relapse. At the time of relapse, only the IL-6 and usCRP levels were significantly higher (p ≤ 0.001) compared with those patients in remission. On multivariate analysis, a high number of double-positive IL-17A + FOXP3 + CD4 + T cells (≥1.4 cells/mm3) and

Frontiers in Immunology frontiersin.org 01

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hal-04872927 , version 1 (08-01-2025)

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Rémi Duclaux-Loras, Gilles Boschetti, Bernard Flourie, Xavier Roblin, Jean-Benoit Leluduec, et al.. Relationships of circulating CD4+ T cell subsets and cytokines with the risk of relapse in patients with Crohn’s disease. Frontiers in Immunology, 2022, 13, ⟨10.3389/fimmu.2022.864353⟩. ⟨hal-04872927⟩
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