Identification of 2,4-Di-tert-Butylphenol as an Antimicrobial Agent Against Cutibacterium acnes Bacteria from Rwandan Propolis - Bordeaux Population Health
Article Dans Une Revue Antibiotics Année : 2024

Identification of 2,4-Di-tert-Butylphenol as an Antimicrobial Agent Against Cutibacterium acnes Bacteria from Rwandan Propolis

Florent Rouvier
Lydia Abou
  • Fonction : Auteur
  • PersonId : 1427264
Emmanuel Wafo
Perrine Andre
  • Fonction : Auteur
  • PersonId : 1488984
Julien Cheyrol
  • Fonction : Auteur
  • PersonId : 1488985
Mohamed-Mohsen Khacef
  • Fonction : Auteur
  • PersonId : 1488986
Jean Michel Brunel

Résumé

Background/Objectives: Acne is the most prevalent dermatological condition among humans, affecting approximately 80% of adolescents during puberty. To date, numerous compounds have been used for acne treatment, including erythromycin ointments and antiseptics, with varying degrees of success. The emergence of erythromycin-resistant C. acnes strains has spurred the search for new antimicrobial agents, particularly from natural sources. Methods: Propolis collected in Rwanda was extracted and fractionated by flash chromatography and tested against C. acnes growth by using NCLSI recommendations. Results: In our research, we identified a molecule, 2,4-Di-tert-butylphenol (2,4-DTBP) which inhivbited the C. acnes growth at a concentration of 16 µg/mL. Based on these results, we formulated an ointment (1%) using OFAP18 and petroleum jelly for the potential treatment of acne using a mouse model. Conclusions: In vitro and in vivo evidence suggests that 2,4-DTBP has anti-inflammatory properties and could effectively manage the overgrowth of C. acnes as well as serve as a potent alternative for the formulation of an active propolis ointment for acne treatment.

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hal-04883825 , version 1 (13-01-2025)

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Florent Rouvier, Lydia Abou, Emmanuel Wafo, Perrine Andre, Julien Cheyrol, et al.. Identification of 2,4-Di-tert-Butylphenol as an Antimicrobial Agent Against Cutibacterium acnes Bacteria from Rwandan Propolis. Antibiotics, 2024, 13, ⟨10.3390/antibiotics13111080⟩. ⟨hal-04883825⟩
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